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What’s In Cannabis?
Cannabis has been utilized for millennia for its therapeutic properties. THC is only a small part of what provides relief when consuming cannabis. This Article aims to distill all known substances derived from cannabis that impact human physiology. we will examine their origins, presence outside the cannabis plant, and clinical use cases supported by research.
Canabanoids
- Delta-9-Tetrahydrocannabinol (THC)
- Origin: THC is primarily derived from the resin of the female cannabis plant.
- Presence Outside Cannabis: It does not occur naturally outside of cannabis but can be synthetically produced.
- Therapeutic Uses: Used in the treatment of chronic pain, nausea, and appetite stimulation in patients undergoing chemotherapy.
- Research: A 2014 study published in the Journal of Pain revealed that THC significantly reduced pain levels in participants compared to placebo.
- Cannabidiol (CBD)
- Origin: CBD is also derived from cannabis, particularly in higher concentrations in industrial hemp.
- Presence Outside Cannabis: Found in trace amounts in some other plants like echinacea or black pepper; synthetic variants are also available.
- Therapeutic Uses: Used for epilepsy (especially Dravet and Lennox-Gastaut syndromes), anxiety management, and anti-inflammatory treatments.
- Research: A 2017 review in the journal “Neuroscience & Biobehavioral Reviews” confirmed CBD’s effectiveness in reducing seizure frequency in epilepsy patients.
- Cannabigerol (CBG)
- Origin: CBG is considered a precursor to other cannabinoids, derived from young cannabis plants.
- Presence Outside Cannabis: Currently, no significant sources have been identified outside cannabis.
- Therapeutic Uses: Potential applications in antimicrobial and anti-inflammatory treatments, as well as appetite stimulant.
- Research: A 2016 study in the journal “Frontiers in Pharmacology” demonstrated CBG’s ability to inhibit cancer cell growth.
- Cannabinol (CBN)
- Origin: CBN is derived from the degradation of THC.
- Presence Outside Cannabis: Not significantly found outside the cannabis plant.
- Therapeutic Uses: Associated with sleep aid and appetite stimulation.
- Research: A 2021 study in “BMC Complementary Medicine and Therapies” indicated that CBN may enhance sleep quality.
- Tetrahydrocannabivarin (THCV)
- Origin: THCV is found in certain cannabis strains, predominantly sativa.
- Presence Outside Cannabis: No alternative sources identified.
- Therapeutic Uses: Exhibits properties that can suppress appetite, making it an interest for obesity treatment, and may have anti-seizure effects.
- Research: A 2013 study published in the “Journal of Psychopharmacology” has shown THCV can reduce anxiety and improve cognitive function.
Terpenes
- Myrcene
- Source: Found in high concentrations in cannabis and in mangoes, hops, and lemongrass.
- Therapeutic Uses: Believed to facilitate the sedative effects of THC, anti-inflammatory properties, and muscle relaxant aspects.
- Research: Studies suggest an enhanced sedative effect in the presence of myrcene when coupled with THC.
- Limonene
- Source: This terpene is found in the rinds of citrus fruits and is present in some cannabis strains.
- Therapeutic Uses: Potential anxiolytic and anti-depressive effects have been noted.
- Research: A 2015 study suggests that limonene has anti-anxiety properties when inhaled.
- Linalool
- Source: Present in lavender, linalool contributes to the characteristic scent of many cannabis strains.
- Therapeutic Uses: Provides calming effects for anxiety and has significant anti-inflammatory properties.
- Research: 2016 studies demonstrated that linalool inhalation reduced stress responses in subjects.
Flavonoids
- Cannaflavin A
- Source: Found in cannabis, particularly in unprocessed strains.
- Therapeutic Uses: Exhibits anti-inflammatory properties and may help in reducing pain.
- Research: Early studies highlight cannaflavins’ effectiveness comparable to aspirin.
Cannabis processing and the synergistic effects of cannabinoids, terpenes, and flavonoids provide a complex interaction with the human endocannabinoid system. Further research is essential to fully articulate the therapeutic potentials of these compounds and their applications in clinical settings. Continuous advancements in our understanding will lead to optimized patient care and novel treatment modalities centered around cannabis-derived substances.
References:
- Latest articles from peer-reviewed journals on clinical applications of cannabinoids.
- Studies from the National Institutes of Health and various pharmacological databases.
Acknowledgments:Grateful appreciation is extended to the researchers and institutions dedicated to ongoing cannabis research and education to promote its safe use in medicine.
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